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Check to make sure you have SMTP Authentication enabled in your email client, which is required by the server in order to send mail. Some ISP's require that you authenticate yourself to their server and use only their smtp server and not your webhost when sending mail.
What is the size of the email you are trying to send? Our servers currently limit outgoing messages to 10MB, however when an email is sent with an attachment - it is encoded, the encoding can raise the size of an email quite a bit. Generally speaking, a 7MB attachment may approach the 10MB limit after encoding.
How many recipients are there for the email being sent? If an email being sent is of mailing-list size, it is generally best to use mailing list software such as MailMan to send the email in batches.
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